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Single-use technologies in downstream bioprocessing operations

Understanding the fundamental knowledge and skills of downstream bioprocessing underpins innovation in the biopharmaceutical industry. This three day course introduces you to key downstream bioprocessing approaches and techniques. Take a proactive approach in applying these skills to downstream operations. Discover single-use technology solutions for downstream bioprocessing.

About this course

Single-use technology is widely used within the biopharmaceutical industry and has quickly become a mainstay within the sector as it facilitates faster, secure, and economical biologics production.

This three day course combines the NIBRT industry training curriculum with industry-focused practical training from UTS to provide a holistic introduction to downstream bioprocessing operations, with a focus on single-use technology.

Gain hands-on practical experience operating downstream purification processes, including chromatography and ultrafiltration/diafiltration.

Course structure

This three day course offers you both a theory and practical learning experience by combining the NIBRT industry training curriculum with hands-on practical sessions from UTS.

You will expand their knowledge on downstream bioprocessing through theory and hands-on practical sessions exploring aseptic connections, a single-use liquid chromatography system, and an ultrafiltration/diafilatration system. 

You will also have the opportunity to practice key downstream bioprocessing principles and skills by preparing and running designed plot-scale protocols in a GMP-lite environment.

Key topics covered

  • Fundamentals of downstream processing for product recovery
  • Single-use technologies in downstream processes
  • Overview of chromatography
  • Overview of ultrafiltration/diafiltration
  • Viral clearance technologies
  • Preparation and operation of a single-use chromatography system
  • Preparation and operation of a single-use UF/DF system.


Learning outcomes

  • Describe the methods available for downstream processing and protein purification.
  • Explain the basic principles of chromatography, filtration, and viral clearance in downstream processing.
  • Perform the key process operations of a single-use chromatography system.
  • Develop the skills to prepare and operate a single-use UF/DF system.
  • Practise GDP to follow and complete SOPs, batch records and logbook.


About the providers

Biologics Innovation Facility

The Biologics Innovation Facility (BIF) is an Australia-first training and bioprocessing facility based at the University of Technology, Sydney. BIF aims to drive the development of the biotech industry by offering a platform for innovation in biopharmaceutical research, as well as providing professional training in bioprocessing techniques in a GMP-lite environment.


National Institute of Bioprocessing Research and Training

The National Institute for Bioprocessing Research and Training (NIBRT) is a global centre of excellence for training and research in biopharmaceutical manufacturing. NIBRT is located in a world class facility in Dublin, Ireland.

This facility is purpose built to closely replicate a modern bioprocessing plant with state-of-the-art equipment and enables NIBRT to offer the highest quality training and research solutions.

NIBRT’s mission is to support the growth and development of all aspects of the biopharmaceutical manufacturing industry.


COVID-19 information

UTS is undertaking a number of social distancing initiatives, informed by NSW Health advice, to help reduce social interactions in support of the government’s efforts to slow the spread of COVID-19. As part of this response, we are postponing the presentation of this course to a later date in 2020.

Enquiries are still being accepted. If you have any questions in the interim, please do not hesitate to email The Biologics Innovation Facility at


Who is this course for?

This course is designed for those wishing to increase their knowledge of upstream operations in a modern bioprocessing plant, including:

  • Operators
  • Technical staff
  • Engineers
  • Managers

This course is also recommended for individuals that are new to single-use technologies, including:

  • Development scientists
  • Process engineers
  • Manufacturing operators


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