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Single-use Technologies in Upstream Bioprocessing Operations

Innovation in the biopharmaceutical industry is driven by adapting fundamental bioprocessing strategies and technologies. This course will introduce you to key upstream bioprocessing concepts and techniques, and bring them into practice through practical experiences operating single-use bioreactors. Explore single-use technology solutions for upstream bioprocessing.

About this course

Single-use technology is widely used within the biopharmaceutical industry and has quickly become a mainstay within the sector as it facilitates faster, secure, and economical biologics production.

This three-day course combines the National Institute for Bioprocessing Research and Training (NIBRT) curriculum with industry-focused practical training from UTS to provide a holistic introduction to upstream operations, with a focus on single-use technology.

You will gain hands-on practical experience operating both small scale and large scale single-use bioreactors in a GMP-Lite environment. 

Course structure 

This three-day course incorporates both theory and a practical learning experience by combining the NIBRT industry training curriculum with hands-on, practical sessions from UTS.

You will gain a foundation knowledge of key upstream operations, highlighting the application of single-use technologies in upstream processing. Engage in hands-on practical experiences using aseptic connections, WAVE bioreactor systems, and a traditional upright 200L single-use bioreactor. You will also have the opportunity to prepare and run designed pilot-scale upstream protocols in a GMP-Lite cleanroom environment. 

A written assessment will be conducted at the end of the course to certify proficiency in the theory and practical content which has been covered.

Key topics covered:

  • Overview of the biopharmaceutical production process
  • Introduction to bioreactor design and operations
  • Single-use technology landscape, applications, advantages, and disadvantages
  • Key upstream operations using single-use technologies
  • Aseptic operation of biosafety cabinets and bioreactors
  • Set up and operation of a 50L WAVE bioreactor system
  • Set up and operation of a 200L single-use bioreactor
  • Mock run of typical upstream processes under GMP-lite cleanroom environment.

Learning outcomes

  • Describe the aseptic culturing of mammalian cells from small to large scale
  • Understand the principles and applications of single-use technology.
  • Discuss the advantages and disadvantages of single-use technology in upstream processing
  • Practise GDP to complete SOPs, batch records and logbook
  • Demonstrate key procedures in the preparation and operation of a single-use WAVE system and 200L bioreactor.

About the providers

Biologics Innovation Facility

The Biologics Innovation Facility (BIF) is an Australia-first training and bioprocessing facility based at the University of Technology, Sydney. BIF aims to drive the development of the biotech industry by offering a platform for innovation in biopharmaceutical research, as well as providing professional training in bioprocessing techniques in a GMP-lite environment.


National Institute of Bioprocessing Research and Training

The National Institute for Bioprocessing Research and Training (NIBRT) is a global centre of excellence for training and research in biopharmaceutical manufacturing. NIBRT is located in a world class facility in Dublin, Ireland.

This facility is purpose built to closely replicate a modern bioprocessing plant with state-of-the-art equipment and enables NIBRT to offer the highest quality training and research solutions.

NIBRT’s mission is to support the growth and development of all aspects of the biopharmaceutical manufacturing industry.


  • $3,600

COVID-19 information

UTS is undertaking a number of social distancing initiatives, informed by NSW Health advice, to help reduce social interactions in support of the government’s efforts to slow the spread of COVID-19. 

Should you have any questions about the course, please do not hesitate to email The Biologics Innovation Facility at

Who is this course for?

This course is designed for those wishing to increase their knowledge of upstream operations in a modern bioprocessing plant, including:

  • Operators
  • Technical staff
  • Engineers
  • Managers.

This course is also recommended for individuals that are new to single-use technologies, including:

  • Development scientists
  • Process engineers
  • Manufacturing operators.


05 May




3 days

Book a session

Wed 05 May 2021 -
Fri 07 May 2021
  • UTS Campus - CB07.Ground Floor.TBC
  • On-campus
  • 3 sessions, 24 hours total
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